OMEPRAZOLE, OTHER ANTIULCER DRUGS AND NEWLY-DIAGNOSED GOUT

Aims Case-reports describing patients who developed a first episode of acute gout while being treated with the proton pump inhibitor omepraz ole led us to compare incidence rates of newly diagnosed gout cases am ong omeprazole, ranitidine and cimetidine users. Methods We conducted a cohort study with a nested case-control analysis using the UK-based General Practitioner Research Database (GPRD). The study encompassed a cohort of more than 53 000 subjects who received some 185 000 prescri ptions for the three study drugs. Results Neither current omeprazole v s recent use (age- and sex-adjusted relative risk 1.1, 95% CI 0.5-2.1) , nor current omeprazole use in comparison with current use of the two histamine H-2-receptor blockers was associated with an increased risk of developing newly diagnosed gout. Higher age (RR 2.4, 95% CI 1.5-3. 9), male gender (RR 5.4, 95% CI 2.8-10.3), high body mass index (OR 3. 3, 95% CI 1.0-10.9) and hypertension (OR 4.5, 95% CI 1.6-12.9) were al l important risk factors for gout. Conclusions While other known risk factors were significantly associated with gout, current omeprazole us e was not materially associated with an increased gout incidence.