Posttransplantation primary cutaneous CD30 (Ki-1)-positive large-cell lymphoma

Organ transplant patients receiving immunosuppressive therapy to prevent al lograft rejection are prone to having malignant tumors develop, the majorit y of which are cutaneous in origin.(1) Posttransplantation lymphoproliferat ive disorders (PTLDs) occur in 1% to 2% of graft recipients and are almost always of B-cell derivation.(2) According to the Cincinnati Transplant Tumo r Registry (CTTR), 14% of lymphoma cases are of T-cell origin.(3) Previousl y, only rare occurrences of primary cutaneous T-cell lymphoma (CTCL) have b een reported.(4) Here, we describe a primary cutaneous CD30-positive large- cell lymphoma (LCL) of T-cell phenotype in a renal transplant recipient and review the literature.