Sl. Flugman et al., Transient eruptive seborrheic keratoses associated with erythrodermic psoriasis and erythrodermic drug eruption: Report of two cases, J AM ACAD D, 45(6), 2001, pp. S212-S214
Tbe appearance of multiple seborrbeic keratoses in association With underly
ing internal malignancy (known as the sign of Leser-Trelat) has generated m
uch discussion and debate in the literature. However, comparatively,few, ca
se reports exist that examine the appearance of multiple seborrheic keratos
es associated with exfoliative erythroderma without underlying malignancy.
We repoly 2 cases it which multiple, biopsy-proven seborrheic keratoses app
eared in conjunction with erythrodermic skin eruptions. The underlying dise
ases in these 2 patients included psoriasis and an eczematous drug eruption
: in both cases the erythroderma resolved with appropriate treatment. After
resolution of the erythroderma. the newly, developed seborrbeic keratoses
proceeded to involute and gradually, fall off. Neither of the patients exhi
bited any, evidence of, internal malignancy. These cases represent the firs
t reports of psoriasis and drug eruption as causes of erythroderma-induced
transient eruptive seborrbeic keratoses. Clinical and pathologic findings a
re consistent with previous descriptions of this entity.