Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation

Authors
Xiao, JH Yuan, G Huang, WQ Lum, JHK Lee, KLD Chan, ASC
Citation
Jh. Xiao et al., Synthesis of nitrated analogs of distamycin and their DNA cleaving and protecting activities under UV irradiation, J CHIN CHEM, 48(5), 2001, pp. 929-932
Citations number
9
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
48
Issue
5
Year of publication
2001
Pages
929 - 932
Database
ISI
SICI code
0009-4536(200110)48:5<929:SONAOD>2.0.ZU;2-V
Abstract
Two nitrated analogs of distamycin were synthesized by a novel haloform rea ction and the DCC/HOBT coupling reaction in a convenient and effective way without amino group protection. Our results have demonstrated that these po lyamides show DNA cleaving activity under long UV (LUV 365 nm) irradiation. Furthermore, it is an unexpected discovery that these analogs can prevent DNA damage under short LTV (SUV 302 nm).