Synthesis of thymidine dimer containing novel (N-acetyl)imino linkage

Authors
Yang, TF Chien, FC Chung, FY
Citation
Tf. Yang et al., Synthesis of thymidine dimer containing novel (N-acetyl)imino linkage, J CHIN CHEM, 48(5), 2001, pp. 949-952
Citations number
14
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
48
Issue
5
Year of publication
2001
Pages
949 - 952
Database
ISI
SICI code
0009-4536(200110)48:5<949:SOTDCN>2.0.ZU;2-T
Abstract
By starting with 3'-keto-5'-O-protected thymidine, 3'-O-amino-5'-t-butyl-di phenylsilyl thymidine (9) was prepared and coupled with 3'-O-t-butyl-diphen yisilyl-5'-formyl thymidine to form a nucleoside dimer (11) containing oxim e linkage. The backbone of this dimer, then, underwent reduction followed b y acetylation to give an (N-acetyl)imino linkage, and a novel dinucleotide (13) was obtained.