Severe reversible bone marrow suppression induced by Selaginella doederleinii

Case Report: We report a 52-year-old-female patient with cholangiocarcinoma who developed severe bone marrow suppression after taking Selaginella doed erleinii as an alternative anticancer treatment. She developed severe pancy topenia with initial presentations of skin ecchymosis, itching, and gum ble eding 2 weeks after taking Selaginella doederleinii daily. Bone marrow smea r and biopsy showed severe hypocellularity, with no malignant cell infiltra tion. Approximately 1 week after stopping Selaginella doederleinii, her hem ogram returned to previous levels. Selaginella doedeleinii, a popular antic ancer herb, may contain an as yet unidentified substance that contributes t o reversible bone marrow suppression.