RAS EFFECTORS AND THEIR ROLE IN MITOGENESIS AND ONCOGENESIS

Pas proteins are membrane-bound GTP-binding proteins that play a criti cal role in the control of cell growth. Through a large number of gene tic and biochemical studies it is becoming increasingly evident that t he biological activity of Pas proteins is mediated by multiple signali ng pathways. This review provides an account of the target proteins th at interact with Pas and the functional consequences of these interact ions. The relative contribution of the different Pas effector pathways to the mitogenic and oncogenic effects of Pas are discussed.