M. Larrosa et al., Prevalence of hypovitaminosis D in elderly institutionalized residents: influence of a sustitutive treatment, MED CLIN, 117(16), 2001, pp. 611-614
BACKGROUND: Osteoporosis in the elderly is a common and severe disease, vit
amin D deficiency being an important causative factor. Hypovitaminosis D is
frequent in old people, particularly those living in nursing homes.
SUBJECTS AND METHOD: We performed a cross-sectional study of 100 randomly r
ecruited elderly institutionalized subjects. The prevalence of hypovitamino
sis D and its possible repercussion on the phosphocalcium metabolism were a
ssessed. The degree of sun exposure and the existence of co-morbidity were
also recorded. Individuals with hypovitaminosis D were included in a longit
udinal study (6 months' duration) aimed at assess the efficacy of treatment
with calcium and two different therapeutic regimens with calcidiol (16,000
IU/week or 16,000 IU every 3 weeks).
RESULTS: 87% of individuals had hypovitaminosis D; 21.8% of them had second
ary hyperparathyroidism. The study population had a low degree of sun expos
ure and a high level of comorbidity. The two doses of calcidiol led to a no
rmalization of 25-OHD3 levels, increased calciuria and compensated secondar
y hyperparathyroidism, yet higher 25-OHD3 levels were achieved with the wee
kly therapeutic scheme.
CONCLUSIONS: Hypovitaminosis D prevalence appears to be very high In the el
derly institutionalized population. Calcium and calcidiol supplementation n
ormalized 25-OHD3. improved calcium absorption and compensaed secondary hyp
erparathyroidism. Calcium and vitamin D supplementation should be employed
routinely in the elderly institutionalized population.