Deconstructing desmoplakin

Authors
Hatsell, S Cowin, P
Citation
S. Hatsell et P. Cowin, Deconstructing desmoplakin, NAT CELL BI, 3(12), 2001, pp. E270-E272
Citations number
21
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
14657392 → ACNP
Volume
3
Issue
12
Year of publication
2001
Pages
E270 - E272
Database
ISI
SICI code
1465-7392(200112)3:12<E270:DD>2.0.ZU;2-D
Abstract
Mature desmosomes are the main adhesive junctions in epithelia and cardiac muscle. Now new work shows that the desmosomal protein desmoplakin is also essential for the maturation of adherens junctions. Desmoplakin clamps down on the transient zippering courtship of the classical cadherins, promoting the maturation of puncta adherens junctions and cortical actin remodelling , steps that are essential for cell adhesion.