Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study

Authors
Sieradzan, KA Fox, SH Hill, M Dick, JPR Crossman, AR Brotchie, JM
Citation
Ka. Sieradzan et al., Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study, NEUROLOGY, 57(11), 2001, pp. 2108-2111
Citations number
9
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
11
Year of publication
2001
Pages
2108 - 2111
Database
ISI
SICI code
0028-3878(200112)57:11<2108:CRLDIP>2.0.ZU;2-P
Abstract
The lateral segment of the globus pallidus (GPI) is thought to be overactiv e in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptor s in the GPI reduces gamma -aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, doubl e-blind, placebo-controlled, crossover trial (n = 7), the authors demonstra te that the cannabinoid receptor agonist nabilone significantly reduces lev odopa-induced dyskinesia in PD.