T. Del Ser et al., Relationship of angiotensin converting enzyme genotype with serum triglyceride concentration in stroke patients, NEUROSCI L, 316(1), 2001, pp. 21-24
The Objective of this research was to study the relationship of angiotensin
converting enzyme (ACE) genotype with serum triglycerides concentration in
stroke patients. The insertion/deletion (I/D) ACE polymorphism was identif
ied by using polymerase chain reaction in 122 prospectively studied ischemi
c stroke patients (age 45-91 years). Serum triglycerides concentration was
determined at admission and 3 months after the stroke, and compared between
the ACE genotype groups (37 D/D, 68 D/I, 17 I/I). All clinical characteris
tics were similar in the three groups. Patients with D/D genotype had mean
serum triglycerides concentration significantly higher in acute (179.0 +/-
111.8 mg/dl) and chronic phase (176.4 +/- 121.6 mg/dl) than those with I/I
genotype (acute phase: 108.7 +/- 36.1 mg/dl, P = 0.019; chronic phase: 116.
0 +/- 44.3 mg/dl, P = 0.021). The results showed that serum triglycerides c
oncentration is elevated in stroke patients with the DID ACE genotype and i
t may be related to the risk of cerebrovascular disease associated with thi
s polymorphism. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.