The first naturally occurring Tie2 kinase inhibitor

Authors
Zhou, BN Johnson, RK Mattern, MR Fisher, PW Kingston, DGI
Citation
Bn. Zhou et al., The first naturally occurring Tie2 kinase inhibitor, ORG LETT, 3(25), 2001, pp. 4047-4049
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
25
Year of publication
2001
Pages
4047 - 4049
Database
ISI
SICI code
1523-7060(200112)3:25<4047:TFNOTK>2.0.ZU;2-A
Abstract
[GRAPHICS] Bioassay-guided fractionation of the plant Acacia aulacocarpa, guided by a bioassay for Tie2 tyrosine kinase activity, yielded the novel triterpene 3, 21-dioxo-olean-18-en-oic acid (1) as the first naturally occurring non-prot ein inhibitor of Tie2 kinase. The structure of 1 was assigned by analysis o f spectral data. In addition to its activity as an inhibitor of Tie2 kinase , compound 1 also shows modest activity against a variety of cultured mamma lian cells.