First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues

Authors
Smith, AB Cho, YS Zawacki, LE Hirschmann, R Pettit, GR
Citation
Ab. Smith et al., First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues, ORG LETT, 3(25), 2001, pp. 4063-4066
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
25
Year of publication
2001
Pages
4063 - 4066
Database
ISI
SICI code
1523-7060(200112)3:25<4063:FGDSAE>2.0.ZU;2-H
Abstract
[GRAPHICS] Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and sy nthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel sca ffolds for the design and:synthesis of cryptophycin analogues.