A rapid access to biaryl ether containing macrocycles by pairwise use of Ugi 4CR and intramolecular SNAr-based cycloetherification

[GRAPHICS] From readily accessible starting materials, macrocycles with an endo aryl-a ryl ether bond are synthesized in only two operations by combination of the Ugi four-component reaction and an intramolecular: SNAr reaction. The nitr o group serves as an activator for the macrocyclization and provides a hand le for the introduction of functional group diversity. A Ugi reaction promo ted by ammonium chloride In aprotic solvent is documented for the first tim e.