Diffuse hemangiomatoses are extremely rare in adults. The etiology and natu
ral history of the disease are not well understood. A case of diffuse heman
giomatosis of the liver and spleen associated with progressive liver failur
e, thrombocytopenia, and disturbance of blood coagulation (comparable to Ka
sabach-Merritt syndrome) is presented in a 62-year-old male. We describe th
e histopathological and immunohistochemical findings and illustrate the mor
phological aspects of differential diagnosis, distinguishing the disease fr
om other vascular proliferations.