A biochemical analysis of people with chronic fatigue who have Irlen syndrome: Speculation concerning immune system dysfunction

This study investigated the biological basis of visual processing disabilit ies in adults with Chronic Fatigue Syndrome. The study involved 61 adults w ith. symptoms of Chronic Fatigue Syndrome who were screened for visual proc essing problems (Irlen Syndrome) and divided into two groups according to t he severity of symptoms of Irlen Syndrome. Significant variations were iden tified in blood lipids and urine amino and organic acids of the two groups, which may be indicative of activation of the immune system due to some inf ective agent. It was suggested that metabolic profiling may help the develo pment of more valid diagnostic categories and allow more investigation of i mmune system dysfunction as a possible causal factor in a range of learning and behaviour disorders.