Ecstasy is a recreational drug that is increasing in popularity, particular
ly in young adolescents. Its appeal involves its euphoric effects and a fee
ling of empathy for others (hence the nickname "hug drug"). This appeal may
be furthered by a misleading and anecdotal perception of safety. Cases of
adverse effects, toxic reactions, and fatalities are increasingly being rep
orted in the medical literature, as well as in the popular press. Adverse e
ffects include hyperthermia, seizures, cardiac abnormalities, and hyponatre
mia. Long-term Ecstasy use may result in serotonin terminal degeneration an
d depletion, which may result in psychiatric and cognitive sequelae. Contro
versy surrounds the legalization of Ecstasy for medicinal purposes.