The single-instanton approximation (SIA) is often used to evaluate analytic
ally instanton contributions to the Euclidean correlation function in QCD a
t small distances. We discuss how this approximation can be consistently de
rived from the theory of instanton ensemble and give precise definitions to
a number of different quark effective masses." generalizing the parameter
m*, which Aas introduced long ago to account for the collective contributio
n of the whole ensemble, We test numerically the range of applicability of
the SIA for different quantities. Furthermore. we determine all the effecti
ve masses (for random and interacting instanton liquid models) as ell as fr
ont phenomenology, and discuss to what extent those are universal.