Search for new synthetic immunosuppressants. Antamanide analogues containing the tetrazole ring as a cis-peptide bond mimetic

Authors
Zubrzak, P Kaczmarek, K Kowalski, ML Szkudlinska, B Zabrocki, J
Citation
P. Zubrzak et al., Search for new synthetic immunosuppressants. Antamanide analogues containing the tetrazole ring as a cis-peptide bond mimetic, POL J CHEM, 75(12), 2001, pp. 1869-1876
Citations number
21
Categorie Soggetti
Chemistry
Journal title
POLISH JOURNAL OF CHEMISTRY
ISSN journal
01375083 → ACNP
Volume
75
Issue
12
Year of publication
2001
Pages
1869 - 1876
Database
ISI
SICI code
0137-5083(200112)75:12<1869:SFNSIA>2.0.ZU;2-G
Abstract
Linear and cyclic antamanide (ANT) analogues with dipeptide segments Pro(2) -Pro(3), Pro(7)-Pro(8) and both of them replaced by their tetrazole analogu e Pro-psi [CN4]-Ala, respectively, have been synthesized by SPPS method and cyclization with TBTU reagent. The peptides were examined for their immuno suppressive activity in a lymphocyte proliferation test (LPT).