Protein threading by learning

Authors
Chang, I Cieplak, M Dima, RI Maritan, A Banavar, JR
Citation
I. Chang et al., Protein threading by learning, P NAS US, 98(25), 2001, pp. 14350-14355
Citations number
38
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
98
Issue
25
Year of publication
2001
Pages
14350 - 14355
Database
ISI
SICI code
0027-8424(200112)98:25<14350:PTBL>2.0.ZU;2-4
Abstract
By using techniques borrowed from statistical physics and neural networks, we determine the parameters, associated with a scoring function, that are c hosen optimally to ensure complete success in threading tests in a training set of proteins. These parameters provide a quantitative measure of the pr opensities of amino acids to be buried or exposed and to be in a given seco ndary structure and are a good starting point for solving both the threadin g and design problems.