Nicotine metabolism by the polymorphic cytochrome P450 2A6 (CYP2A6) enzyme: Implications for interindividual differences in smoking behaviour target article on nicotine-addiction

Authors
Oscarson, M
Citation
M. Oscarson, Nicotine metabolism by the polymorphic cytochrome P450 2A6 (CYP2A6) enzyme: Implications for interindividual differences in smoking behaviour target article on nicotine-addiction, PSYCOLOQUY, 12(3), 2001, pp. NIL_3-NIL_8
Citations number
25
Categorie Soggetti
Psycology
Journal title
PSYCOLOQUY
ISSN journal
10550143 → ACNP
Volume
12
Issue
3
Year of publication
2001
Pages
NIL_3 - NIL_8
Database
ISI
SICI code
1055-0143(2001)12:3<NIL_3:NMBTPC>2.0.ZU;2-#
Abstract
Cytochrome P450 2A6 (CYP2A6) is one of the most important enzymes in human nicotine metabolism. Genetic polymorphisms in the CYP2A6 gene causes import ant interindividual variability in CYP2A6 activity and this variation can e xplain some of the interindividual variability in nicotine metabolism previ ously reported. Here I summarise the current knowledge about the CYP2A6 pol ymorphism, and also discuss the potential importance of this polymorphism f or differences in smoking behaviour.