The authors present a 3-year-old girl in whom severe hyperphosphatemia
and hypocalcemia developed after the administration of three adult-si
zed hypertonic phosphate enemas. The commonly held notion that these e
nemas are not absorbed and therefore are systemically inactive is inco
rrect. With early intervention and treatment, the child survived witho
ut sequelae despite a serum phosphate level (74.7 mg/dL) that is great
er than those previously reported. The treatment of hyperphosphatemia
is reviewed as well as underlying pathology such as altered gastrointe
stinal motility and renal insufficiency, which may predispose the pati
ent to this problem. Physicians should be aware of the possible advers
e effects that can be caused by hypertonic phosphate enemas. Copyright
(C) 1997 by W.B. Saunders Company.