Mechanisms of transcriptional memory

Authors
Francis, NJ Kingston, RE
Citation
Nj. Francis et Re. Kingston, Mechanisms of transcriptional memory, NAT REV MOL, 2(6), 2001, pp. 409-421
Citations number
119
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE REVIEWS MOLECULAR CELL BIOLOGY
ISSN journal
14710072 → ACNP
Volume
2
Issue
6
Year of publication
2001
Pages
409 - 421
Database
ISI
SICI code
1471-0072(200106)2:6<409:MOTM>2.0.ZU;2-O
Abstract
How can the same gene remember that it is 'off' in one cell lineage and 'on ' in another? Studies of how homeotic genes are regulated in Drosophila mel anogaster have uncovered a transcriptional maintenance system, encoded by t he Polycomb and trithorax group genes, that preserves expression patterns a cross development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.