The junction-resolving enzymes

Authors
Lilley, DMJ White, MF
Citation
Dmj. Lilley et Mf. White, The junction-resolving enzymes, NAT REV MOL, 2(6), 2001, pp. 433-443
Citations number
91
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE REVIEWS MOLECULAR CELL BIOLOGY
ISSN journal
14710072 → ACNP
Volume
2
Issue
6
Year of publication
2001
Pages
433 - 443
Database
ISI
SICI code
1471-0072(200106)2:6<433:TJE>2.0.ZU;2-G
Abstract
Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch poi nts, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structu ral selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.