Auditory event-related potentials (P300) in epileptic patients

Auditory event-related potentials (AERPs) were recorded during an auditory oddball paradigm in 108 epileptics and in 32 healthy controls. P300 latency Varied in relationship with age only in controls. Symptomatic epileptics h ad significantly prolonged P300 mean latency compared to those without dete ctable brain lesion(s) on MR scan. Moreover, these latter patients were com pared on the basis of epilepsy duration, type of seizure, seizure frequency and antiepileptic treatment, the application of a multiple regression mode l showed a significant relationship between P300 latency prolongation and e pilepsy duration, seizure frequency and polytherapy. (C) 2001 Editions scie ntifiques et medicates Elsevier SAS.