Molecular physiology of renal p-aminohippurate secretion

Authors
Burckhardt, G Bahn, A Wolff, NA
Citation
G. Burckhardt et al., Molecular physiology of renal p-aminohippurate secretion, NEWS PHYSL, 16, 2001, pp. 114-118
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
16
Year of publication
2001
Pages
114 - 118
Database
ISI
SICI code
0886-1714(200106)16:<114:MPORPS>2.0.ZU;2-B
Abstract
Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs b y exchange with intracellular alpha -ketoglutarate and is mediated by the o rganic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.