An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility

Authors
Cingolani, HE Perez, NG de Hurtado, MCC
Citation
He. Cingolani et al., An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility, NEWS PHYSL, 16, 2001, pp. 88-91
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
16
Year of publication
2001
Pages
88 - 91
Database
ISI
SICI code
0886-1714(200104)16:<88:AAMTBM>2.0.ZU;2-8
Abstract
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased forma tion of endothelin, activation of the Na+/H+ exchanger, increase in intrace llular Na+ and the increase in the Ca2+ transient that underlies the slow f orce response to stretch. The autocrine/paracrine mechanism could explain h ow changes in afterload alter cardiac contractility.