Synthesis of a new bisphosphonic acid ligand (SEDP) and preparation of a Re-188-(Sn)SEDP bone seeking radiotracer

Authors
Lisic, EC Phillips, M Ensor, D Nash, KL Beets, A Knapp, FF
Citation
Ec. Lisic et al., Synthesis of a new bisphosphonic acid ligand (SEDP) and preparation of a Re-188-(Sn)SEDP bone seeking radiotracer, NUCL MED BI, 28(4), 2001, pp. 419-424
Citations number
27
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
09698051 → ACNP
Volume
28
Issue
4
Year of publication
2001
Pages
419 - 424
Database
ISI
SICI code
0969-8051(200105)28:4<419:SOANBA>2.0.ZU;2-O
Abstract
The new bisphosphonate ligand SEDP (2-sulfonato-1,1-ethylidene bisphosphoni c acid) has been synthesized and characterized, including the determination of the protonation constants, and used to form Re-188-(Sn)SEDP from (NaReO 4)-Re-188. The title compound Re-188-(Sn)SEDP shows slightly greater bone u ptake and less kidney uptake than Re-188-(Sn)HEDP in rat biodistribution st udies. (C) 2001 Elsevier Science Inc. All rights reserved.