Fish oil suppressed cytokines and nuclear factor-kappaB induced by murine AIDS virus infection

The effects of dietary fish oil on pro-inflammatory cytokines, nuclear fact or-kappaB (NF-KB) and viral replication were studied in a murine model of A IDS. Sixty-four female C57BL/6 mice were divided into two dietary groups an d fed either a corn oil or fish oil diet. After 4 weeks, each group was div ided into two subgroups. One subgroup from each group was infected with LP- BM5 murine leukemia virus. At 4 and 10 weeks post-infection, one-half of th e mice were sacrificed. Blood samples, and the spleens and livers were coll ected. The results demonstrated that when compared to corn oil, fish oil pa rtially suppressed the virus-induced overproduction of serum IgG and IgM an d the in vitro LPS-stimulated production of leukotriene B,, tumor necrosis factor-cr and interleukin-la in splenocytes, Fish oil also partially suppre ssed NF-KB activation and viral replication in both tissues when compared t o corn oil. (C) 2001 Elsevier Science Inc. All rights reserved.