We have studied the phonon-induced effective interactions between charge ca
rriers (holes) in a three-band model of the CuO2 plane of high-temperature
superconductors. For the phononic part we have included two oxygen phonon m
odes, breathing and buckling, and two types of electron-phonon interactions
: namely, the ionic coupling, for which the displaced oxygens influence the
energy level on copper, and the covalent coupling, for which the Cu-O hopp
ing is modified by the displaced oxygens. Using a cell-perturbation method
we have calculated the effective interaction between holes, V-hh, as induce
d by the electron-phonon couplings. We have found that the attractive inter
action between holes, due to the breathing mode, is maximum in the presence
of finite electron correlation. Furthermore, the presence of the buckling
mode enhances the attractive interactions. We show that the calculated valu
es of V-hh are of the same order as the values of the electronic pseudogap
Delta, found in the normal state of the cuprates. We demonstrate that the i
sotope effect, related to the substitution O-16 --> O-18, changes the calcu
lated values of V-hh in a way consistent with the experimentally found isot
ope effect of Delta. Finally, we have evaluated the superconducting transit
ion temperature T-c and found a qualitative agreement with the experimental
phase diagrams of the cuprates.