Bisbenzisoselenazol-3(2H)-ones, a new group of ebselen analogues

The title compounds with benzisoselenazolone moieties connected by spacers such as phenylene, bisphenylene, alkylene, oxaalkylene, azaalkylene and dit hiaalkylene groups have been obtained in the reaction of 2-(chloroseleno)be nzoyl chloride with compounds having two primary amine groups, while the se condary amines gave products of their selenenylation and/or acylation. Bisb enzisoselenazl-3(2H)-ones were found, in the antiviral assay in vitro, to b e inhibitors of cytopathic activity of RNA and DNA viruses: EMCV, HSV-1 and VSV.