Hepatocellular carcinoma with biliary tumor thrombi: Aggressive operative approach after appropriate preoperative management

Background. The aim of this study was to clarify clinicopathologic characte ristics of and to evaluate an aggressive treatment strategy for hepatocellu lar carcinoma with biliary tumor thrombi. Methods. From 1980 to 1999 a total of 132 patients underwent hepatectomy fo r hepatocellular carcinoma. Of these, 17 patients had macroscopic biliary t umor thrombi and were retrospectively analyzed. Results. The operative procedures included right hepatic trisegmentectomy ( n = 1), light or left hepatic lobectomy (n = 11), and segmentectomy or subs egmentectomy (n = 5). In 13 patients, tumor thrombi extended beyond the hep atic confluence and was treated by thrombectomy through a choledochotomy in 8 patients and extrahepatic bile duct resection and reconstruction in 5 pa tients. The 3- and 5-year survival rates were 47% and 28%, respectively, wi th a median survival time of 2.3 yews. These survival rates were similar to those achieved in 115 patients without biliary tumor thrombi. In a multiva riate analysis, expansive growth type and solitary tumors were independent prognostic variables for favorable outcome after operation, whereas biliary tumor thrombi was not a significant prognostic factor Conclusions. Surgery after appropriate preoperative management of hepatocel lular carcinoma with biliary tumor thrombi yields results similar to those of patients without biliary involvement. Hepatectomy with thrombectomy thro ugh a choledochotomy appears to be as effective as a resection procedure.