Cytochrome P450BM3 and its F87V mutant were exploited for a convenient, lab
oratory scale (1 mmol) preparation of 14(S), 15(R)-epoxyeicosatrienoic acid
[14(S),15(R)-EET] from arachidonic acid and (+)-leukotoxin B [(+)-12(S),13
(R)-vernolic acid] from linoleic acid, respectively. Their enantiomers were
accessed via a four-step chemical inversion. (C) 2001 Elsevier Science Ltd
. Ail rights reserved.