Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)

Authors
Falck, JR Reddy, YK Haines, DC Reddy, KM Krishna, UM Graham, S Murry, B Peterson, JA
Citation
Jr. Falck et al., Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid), TETRAHEDR L, 42(25), 2001, pp. 4131-4133
Citations number
34
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
25
Year of publication
2001
Pages
4131 - 4133
Database
ISI
SICI code
0040-4039(20010618)42:25<4131:PESO1A>2.0.ZU;2-P
Abstract
Cytochrome P450BM3 and its F87V mutant were exploited for a convenient, lab oratory scale (1 mmol) preparation of 14(S), 15(R)-epoxyeicosatrienoic acid [14(S),15(R)-EET] from arachidonic acid and (+)-leukotoxin B [(+)-12(S),13 (R)-vernolic acid] from linoleic acid, respectively. Their enantiomers were accessed via a four-step chemical inversion. (C) 2001 Elsevier Science Ltd . Ail rights reserved.