A biosynthetic microbial ability applied for the oxidative ring cleavage of non-natural heterocyclic quinones

Authors
Le Texier, L Roy, S Fosse, C Neuwels, M Azerad, R
Citation
L. Le Texier et al., A biosynthetic microbial ability applied for the oxidative ring cleavage of non-natural heterocyclic quinones, TETRAHEDR L, 42(25), 2001, pp. 4135-4137
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
25
Year of publication
2001
Pages
4135 - 4137
Database
ISI
SICI code
0040-4039(20010618)42:25<4135:ABMAAF>2.0.ZU;2-W
Abstract
The regiospecific oxidative ring cleavage of naphthooxazole and naphthooxaz ole quinonic derivatives was performed by a microbial methodology using a S treptomyces strain. The subsequent C-C bond cleaved products were new 2-sub stituted-5-(2-hydroxybenzoyl)thiazole or oxazole-4-carboxylic acid derivati ves obtained in one step with 30-65% yields. (C) 2001 Elsevier Science Ltd. All rights reserved.