Citation
Sg. Kim et Kh. Ahn, Enantioselective Michael addition catalyzed by chiral tripodal oxazoline-tBuOK complexes, TETRAHEDR L, 42(25), 2001, pp. 4175-4177
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039
→ ACNP
Volume
42
Issue
25
Year of publication
2001
Pages
4175 - 4177
Database
ISI
SICI code
0040-4039(20010618)42:25<4175:EMACBC>2.0.ZU;2-Y
Abstract
Benzene-based tripodal oxazolines are found to be novel chiral ligands for
the catalytic enantioselective Michael addition via potassium enolates. Thu
s, methyl phenylacetate undergoes 1,4-addition to methyl acrylate using a c
atalytic amount of a tBuOK-oxazoline complex in toluene at -78 degreesC, an
d up to 82% ee is obtained. (C) 2001 Elsevier Science Ltd. All rights reser
ved.