Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics

Authors
Yu, JQ Spencer, JB
Citation
Jq. Yu et Jb. Spencer, Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics, TETRAHEDR L, 42(25), 2001, pp. 4219-4221
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
25
Year of publication
2001
Pages
4219 - 4221
Database
ISI
SICI code
0040-4039(20010618)42:25<4219:CSO2A2>2.0.ZU;2-4
Abstract
2-Deoxy-scyllo-inosose 1 and 2-deoxy-scyllo-inosamine 2 are two of the key intermediates on the biosynthetic pathway to 2-deoxystreptamine-containing aminoglycoside antibiotics. Convenient syntheses of 1, 2 and tritium-labell ed 2 via stereoselective deoxygenation of myo-inositol using LTBH are repor ted. This should provide the substrates necessary for characterising the en zymes involved on the biosynthetic pathway. (C) 2001 Elsevier Science Ltd. All rights reserved.