New polymer-supported chiral phase-transfer catalysts in the asymmetric synthesis of alpha-amino acids: the role of a spacer

Authors
Thierry, B Plaquevent, JC Cahard, D
Citation
B. Thierry et al., New polymer-supported chiral phase-transfer catalysts in the asymmetric synthesis of alpha-amino acids: the role of a spacer, TETRAHEDR-A, 12(7), 2001, pp. 983-986
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
7
Year of publication
2001
Pages
983 - 986
Database
ISI
SICI code
0957-4166(20010508)12:7<983:NPCPCI>2.0.ZU;2-2
Abstract
Polymer-supported cinchona alkaloid salts with different spacers were used as phase-transfer catalysts in the asymmetric C-alkylation of N-diphenyl me thylene glycine tert-butyl ester. Various catalysts and alkylation conditio ns were studied, the best result being 81% e.e. with cinchoninium iodide bo und to polqstyrene with a four-carbon spacer. (C) 2001 Elsevier Science Ltd . All rights reserved.