Synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyridinyl)propanoate ananalog of L-azatyrosine

Authors
Adamczyk, M Reddy, RE
Citation
M. Adamczyk et Re. Reddy, Synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyridinyl)propanoate ananalog of L-azatyrosine, TETRAHEDR-A, 12(7), 2001, pp. 1047-1054
Citations number
29
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
7
Year of publication
2001
Pages
1047 - 1054
Database
ISI
SICI code
0957-4166(20010508)12:7<1047:SO(3A>2.0.ZU;2-C
Abstract
A concise asymmetric synthesis of (R)-(+)-methyl 3-amino-3-(5-hydroxy-2-pyr idinyl)propanoate 2. a beta -amino acid analog of L-azatyrosine 1 starting from the commercially available (-)-Andersen reagent (-)-3 in good overall yield is described. (C) 2001 Elsevier Science Ltd. All rights reserved.