HLA class II antigens in South African blacks with type I diabetes

Citation
Fj. Pirie et al., HLA class II antigens in South African blacks with type I diabetes, TISSUE ANTI, 57(4), 2001, pp. 348-352
Citations number
14
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
00012815 → ACNP
Volume
57
Issue
4
Year of publication
2001
Pages
348 - 352
Database
ISI
SICI code
0001-2815(200104)57:4<348:HCIAIS>2.0.ZU;2-U
Abstract
Type 1 diabetes mellitus is poorly characterised in many African communitie s, including South Africa, where little is known of the disease epidemiolog y. This study aimed to identify the HLA class II alleles associated with ty pe 1 diabetes in a group of Zulu subjects in Durban, KwaZulu-Natal by PCR-S SP. The HLA alleles associated with type 1 diabetes included HLA-DQB*0302 ( P <0.0001), DRB1*O9 (P <0.0001), DRB1*04 (P=0.002), DRB1*0301 (P=0.003), DQ B*02 (P=0.004) and DQA*03 (P=0.035). Estimated haplotypes positively associ ated with type 1 diabetes included HLA-DRB1 *0301-DQA*0501, DRB1*04-DQA*03, DRB1*04-DQB*0302, DRB1*0301-DQB*0201, D&A*0501-DQB*0201 and D&A*03-DQB*030 2. These findings are similar to those reported from Zimbabwe and other pop ulations with type 1 diabetes.