The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices

Citation
C. Herholz et al., The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices, VET RES COM, 25(5), 2001, pp. 401-412
Citations number
20
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY RESEARCH COMMUNICATIONS
ISSN journal
01657380 → ACNP
Volume
25
Issue
5
Year of publication
2001
Pages
401 - 412
Database
ISI
SICI code
0165-7380(2001)25:5<401:TVAROI>2.0.ZU;2-9
Abstract
Several indices of ventilatory heterogeneity can be identified from the vol umetric capnogram and its graphic presentation, the single-breath diagram f or CO2 (SBD-CO2). Physiologically based indices of pulmonary function (VTE, VCO2, FACO2, VDBohr, VDBohr%, VD/VTE, A(1)/A(2)) were calculated for healt hy horses (group I, n = 5) and for horses with subclinical (group II, n = 7 ) or clinically manifest chronic obstructive pulmonary disease (COPD) (grou p III, n = 8) during tidal breathing and after medication with lobelin hydr ochloride (Lobelin). We investigated the variability and repeatability of t he lung function indices in healthy horses and in those with COPD both duri ng tidal breathing and after administration of Lobelin, a centrally acting respiratory stimulant. In particular, we were interested in whether the dis criminating ability of SBD-CO2-derived lung function indices would be incre ased between different patient groups after administration of Lobelin compa red to those for the resting values. Of the indices studied, VTE, FACO2, VD Bohr% and A(1)/A(2) appeared to be those with good to excellent repeatabili ty in discriminating healthy horses from those with COPD. Stimulating respi ration with Lobelin gave no advantage in the repeatability of the lung func tion indices or in differentiating between horses with different degrees of COPD.