Vb. Patel et al., Cardioprotective effect of propranolol from alcohol-induced heart muscle damage as assessed by plasma cardiac troponin-T, ALC CLIN EX, 25(6), 2001, pp. 882-889
Background: Heavy alcohol consumption from either long-term misuse or binge
drinking is associated with poor cardiac contractility, mitochondrial dysf
unction, and ventricular arrhythmias. The aim of this study was to measure
circulating cardiac troponin-T as a marker for myocardial damage following
acute and chronic alcohol administration.
Methods: In acute studies, male Wistar rats were treated with alcohol (75 m
mol/kg body weight, intraperitoneal) and plasma was collected 2.5 hr after
alcohol administration for analysis of rat cardiac troponin-T. In addition,
rats were pretreated with cyanamide tan inhibitor of acetaldehyde dehydrog
enase), various beta-blockers, xanthine oxidase inhibitors, or lisinopril b
efore acute alcohol dosing, In chronic studies, rats were fed alcohol las 3
5% of total dietary calories) for 6 weeks.
Results: The results of the time course study showed that acute alcohol adm
inistration significantly raised plasma cardiac troponin-T levels after 2.5
hr and 6 hr, but not after 24 hr. The effects of alcohol on cardiac tropon
in-T were potentiated with cyanamide pretreatment. Acute ethanol, alone or
with cyanamide pretreatment, decreased systolic blood pressure and increase
d heart rates. Beta-blocker pretreatment with propranolol reduced the alcoh
ol-induced increase in plasma troponin-T, whereas lisinopril potentiated th
is effect. The beta-blockers, atenolol and metoprolol, and the xanthine oxi
dase inhibitors, allopurinol and oxypurinol, were unable to reduce elevated
troponin-T. However, pretreatment with the beta-blocker timolol moderated
the acute alcohol-induced increase in troponin-T. In the chronic alcohol ra
t model, no differences were observed between alcohol and control pair-fed
rats, suggesting the inducement of tolerance.
Conclusions: In conditions of acute exposure, ethanol-induced lesions are c
haracterized by raised plasma cardiac troponin-T possibly due to beta (1) a
nd/or beta (2) adrenergic activation.