Ganglion cysts of the knee are being reported more frequently secondary to
an increased rate of magnetic resonance imaging studies. Although knee pain
is the impetus for imaging, ganglion cysts are often incidental findings.
Nonoperative treatment is a successful therapeutic option, We report a pati
ent with variable pain presentations over the course of her treatment. The
pattern of complaints pointed to different primary etiologies about the kne
e, but all were common to an interosseous ganglion cyst, A stepwise assessm
ent and expansion of the differential diagnosis allowed for appropriate uti
lization of modalities and limited morbidity with nonoperative therapy.