Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand

Citation
P. Wilairatna et al., Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand, AM J TROP M, 63(5-6), 2000, pp. 290-294
Citations number
19
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00029637 → ACNP
Volume
63
Issue
5-6
Year of publication
2000
Pages
290 - 294
Database
ISI
SICI code
0002-9637(200011/12)63:5-6<290:CTOSTO>2.0.ZU;2-2
Abstract
One hundred and fifty patients with severe falciparum malaria were administ ered sequential combination of dihydroartemisinin suppository followed by a n oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/ capsule) were given rectally once daily for 3 days with a total dose of 8-10 mg/kg. Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72 hr and 84 hr, respectively. The mean [SD] parasite clearance time and feve r clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No d eath or major adverse drug effects occurred. The cure rate at 28 days of in patient follow-up was 95% (113 of 119 patients). In severe malaria, dihydro artemisinin suppository followed by oral mefloquine is a suitable alternati ve treatment to parenteral drugs.