P. Wilairatna et al., Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand, AM J TROP M, 63(5-6), 2000, pp. 290-294
Citations number
19
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
One hundred and fifty patients with severe falciparum malaria were administ
ered sequential combination of dihydroartemisinin suppository followed by a
n oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/ capsule)
were given rectally once daily for 3 days with a total dose of 8-10 mg/kg.
Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72
hr and 84 hr, respectively. The mean [SD] parasite clearance time and feve
r clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No d
eath or major adverse drug effects occurred. The cure rate at 28 days of in
patient follow-up was 95% (113 of 119 patients). In severe malaria, dihydro
artemisinin suppository followed by oral mefloquine is a suitable alternati
ve treatment to parenteral drugs.