Atherosclerosis represents a spectrum of pathologic lesions with diverse cl
inical sequelae. In this review, we build upon the paradigm that arterioscl
erosis represents an inflammatory disease. By examining mechanisms involved
in the response to vascular injury, we can more effectively implement targ
eted therapy aimed at halting or regressing arteriosclerosis. (C) 2001 by T
he Society of Thoracic Surgeons.