Biomolecular solid state NMR: Advances in structural methodology and applications to peptide and protein fibrils

Solid state nuclear magnetic resonance (NMR) methods can provide atomic-lev el structural constraints on peptides and proteins in forms that are not am enable to characterization by other high-resolution structural techniques, owing to insolubility, high molecular weight, noncrystallinity, or other ch aracteristics. Important examples include peptide and protein fibrils and m embrane-bound peptides and proteins. Recent advances in solid state NMR met hodology aimed at structural problems in biological systems are reviewed. T he power of these methods is illustrated by experimental results on amyloid fibrils and other protein fibrils.