Elevated C-reactive protein - Another component of the atherothrombotic profile of abdominal obesity

Recent studies have suggested that elevated plasma C-reactive protein (CRP) levels are associated with the features of insulin resistance syndrome. In the present study, we have examined the contribution of body composition m easured by hydrostatic weighing and of abdominal adipose tissue (AT) accumu lation assessed by computed tomography to the variation in plasma CRP level s associated with atherogenic dyslipidemia of the insulin resistance syndro me in a sample of 159 men, aged 22 to 63 years, covering a wide range of ad iposity (body mass index values from 21 to 41 kg/m(2)), Plasma CRP levels s howed positive and significant correlations with body fat mass (r=0.41, P < 0.0001), waist girth (r=0.37, P <0.0001), and visceral AT accumulation meas ured by computed tomography at L4 to L5 (r=0.28, P <0.0003). Although CRP l evels were associated with plasma insulin levels measured in the fasting st ate and after a 75-g oral glucose load, no significant correlations were fo und with plasma lipoprotein levels. Finally, comparison of body fatness, of abdominal fat accumulation, and of the features of the insulin resistance syndrome across quintiles of CRP revealed major differences in body fatness and in indices of abdominal AT accumulation between the lowest and the hig hest CRP quintiles, whereas no significant differences were found for varia bles of the plasma lipoprotein-lipid profile. These results suggest that ob esity and abdominal AT accumulation are the critical correlates of elevated plasma CRP levels found in men with atherogenic dyslipidemia of the insuli n resistance syndrome.