Involvement of secretory phospholipase A(2) in the action of melatonin on the indomethacin-induced gastric lesions in the rat

Authors
Kohut, A Sedlakova, A Kalina, I
Citation
A. Kohut et al., Involvement of secretory phospholipase A(2) in the action of melatonin on the indomethacin-induced gastric lesions in the rat, BIOLOGIA, 56(3), 2001, pp. 329-332
Citations number
20
Categorie Soggetti
Biology
Journal title
BIOLOGIA
ISSN journal
00063088 → ACNP
Volume
56
Issue
3
Year of publication
2001
Pages
329 - 332
Database
ISI
SICI code
0006-3088(200106)56:3<329:IOSPAI>2.0.ZU;2-H
Abstract
Melatonin has been suggested to play an important role in the pathogenesis of gastric mucosal lesions. The aim of this study was to examine the in viv o effect of melatonin on indomethacin induced gastric lesions in rats. The activity of secretory phospholipase A(2) (sPLA(2)) in relation to the gastr ic lesion length was also studied. Our results show that indomethacin induc ed gastric lesions were significantly decreased after melatonin pretreatmen t (1, 5 and 10 mg.kg(-1) intraperitoneally). Effect of melatonin was relate d to the PLA(2) activity. Melatonin significantly decreased indomethacin st imulated PLA(2) activity (p < 0.01). The results show marked protection of melatonin against indomethacin-induced gastric lesions. Gastric lesions and the protective effect of melatonin mag be related to the decrease of sPLA( 2) activity.