Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus

Authors
Auclair, K Kennedy, J Hutchinson, CR Vederas, JC
Citation
K. Auclair et al., Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus, BIOORG MED, 11(12), 2001, pp. 1527-1531
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
12
Year of publication
2001
Pages
1527 - 1531
Database
ISI
SICI code
0960-894X(20010618)11:12<1527:COCNTL>2.0.ZU;2-M
Abstract
Investigation of the post-PKS biosynthetic steps to the cholesterol-lowerin g agent lovastatin (1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L (3) , shows that 7 and 3 are precursors to 1, and demonstrates that lovastatin diketide synthase (lovF protein) does not require lovC. (C) 2001 Elsevier S cience Ltd. All rights reserved.