Amidino benzimidazole inhibitors of bacterial two-component systems

Authors
Weidner-Wells, MA Ohemeng, KA Nguyen, VN Fraga-Spano, S Macielag, MJ Werblood, HM Foleno, BD Webb, GC Barrett, JF Hlasta, DJ
Citation
Ma. Weidner-wells et al., Amidino benzimidazole inhibitors of bacterial two-component systems, BIOORG MED, 11(12), 2001, pp. 1545-1548
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
12
Year of publication
2001
Pages
1545 - 1548
Database
ISI
SICI code
0960-894X(20010618)11:12<1545:ABIOBT>2.0.ZU;2-7
Abstract
Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two-component system (TCS). Many of these inhibitors exhibit goo d in vitro antibacterial activity against a variety of susceptible and resi stant Gram-positive organisms. The moiety at the 2-position of the benzimid azole was extensively modified. In addition, the regioisomeric benzoxazoles , heterocyclic replacements for the benzimidazole, have been synthesized an d their activity against the TCS evaluated. (C) 2001 Elsevier Science Ltd. All rights reserved.