Cell permeability as a parameter for lead generation in the protein tyrosine kinase inhibition field

Authors
Papageorgiou, C Camenisch, G Borer, X
Citation
C. Papageorgiou et al., Cell permeability as a parameter for lead generation in the protein tyrosine kinase inhibition field, BIOORG MED, 11(12), 2001, pp. 1549-1552
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
12
Year of publication
2001
Pages
1549 - 1552
Database
ISI
SICI code
0960-894X(20010618)11:12<1549:CPAAPF>2.0.ZU;2-0
Abstract
Based on the inverse relationship between polar surface area and cell perme ability and capitalizing on the properties of pyrrolopyrimidines 1 as prote in tyrosine kinase inhibitors, pyrrolopyridones 2 were designed and synthes ized as potential leads for the development of novel inhibitors with improv ed cell permeability properties. (C) 2001 Elsevier Science Ltd. All rights reserved.